Efficient Synthesis and Anti-Tubercular Activity of a Series of Spirocycles: An Exercise in Open Science
Figure 2
Potential for the rapid synthesis of Spiros analogues via a common 2° amine intermediate 3.
(A) An existing oxa-Pictet–Spengler reaction can be used to form the spirocycle core (blue) as the 2° amine 3 [12]. (B) Strategy to diversify from the 2° core 3 to produce Spiros analogues (C) with variation at the piperidine nitrogen (red).