Discovery and Characterization of a Potent and Selective Inhibitor of Aedes aegypti Inward Rectifier Potassium Channels
Figure 7
The dose-response curve of the toxic effects of VU625 on adult female mosquitoes (A. aegypti) is biphasic.
Normalized percent mortality of mosquitoes at 24 h post-injection. Each mosquito was injected with 69 nL of the vehicle containing probenecid (50 mM) and an appropriate concentration of VU625 to deliver the doses of VU625 indicated and 3.4 nmol of probenecid. The ED25 and ED75 were determined by fitting a non-linear biphasic curve to the data. n = 3–4 trials of 10 mosquitoes each per dose.