Effects of Danshensu on Platelet Aggregation and Thrombosis: In Vivo Arteriovenous Shunt and Venous Thrombosis Models in Rats
Figure 6
Direct effect of various concentrations of danshensu and aspirin on the enzymatic activities of COX-1 and COX-2.
Danshensu and aspirin (water, as a control) were incubated with COX-1 (A) or COX-2 (B) for 10 min and then AA was added. COX enzyme activities are reflected by the amount of PGE2 produced. PGE2 production was measured by ELISA. Enzyme activity in the sample without treatment (water alone) served as control and results are expressed as inhibitory rate of COX-1 and COX-2 activity compared with solvent control.