Optimal Chemotherapy for Leukemia: A Model-Based Strategy for Individualized Treatment
Figure 14
Optimal dosing based on leukocyte count and MCV as target.
A. Evolution of leukocyte count in response to optimum 6-MP dosing. B. Evolution of ΔMCV response with optimum 6-MP dose. Dashed lines represent critical leukocyte and target MCV levels and solid dots represent clinical data for an average patient. C. Optimum 6-MP dosing profile predicted by NMPC. The standard daily 6-MP dosing is 75 mg/day.