Optimal Chemotherapy for Leukemia: A Model-Based Strategy for Individualized Treatment
Figure 2
Schematic representation of 6-MP metabolism.
Following oral intake to the gut, 6-MP is absorbed into the plasma from where it is eliminated through various routes. From plasma, 6-MP diffuses into the cells and enzymatically converted to 6-TGN and MeMP, which in turn are eliminated from the cells at a constant rate.