Lymphocyte Activation Gene 3 (LAG-3) Modulates the Ability of CD4 T-cells to Be Suppressed In Vivo
Figure 6
Decreased FOXP3 Treg induction in LAG-3 KO T-cells in an in vivo self-tolerance.
A) WT or LAG-3 KO 6.5 TCR Transgenic CD4+ T-cells adoptively transferred into C3-HA expressing mice. B) FOXP3 and C) Tbet expression was analyzed and representative graphs shown. C–D) Summary of FOXP3 expression in adoptively transferred cells. E–F) Summary of TBET expression in adoptively transferred cells. Data shown are representative of at least two independent experiments where n = 4 mice per group.