Lymphocyte Activation Gene 3 (LAG-3) Modulates the Ability of CD4 T-cells to Be Suppressed In Vivo
Figure 3
FOXP3 Treg are required for LAG-3 Blockade to augment homeostatic proliferation in vivo.
A) 1E6 FOXP3 DTR CD4+ T-cells transferred into RAG KO mice. Isotype control antibody or LAG-3 blocking antibody was given every 2 days with either PBS or Diphtheria Toxin. B) FOXP3 expression by flow cytometry ICS. C) Percent of CD4+ T-cells expressing FOXP3 D) Serum IL-2 levels by ELISA. Data shown are representative of at least two independent experiments with n = 4 mice per group.