Inhibition of Kidney Proximal Tubular Glucose Reabsorption Does Not Prevent against Diabetic Nephropathy in Type 1 Diabetic eNOS Knockout Mice
Figure 2
Diabetic mice demonstrated increased glomerulosclerosis and glomerular fibronectin deposition, which was improved by telmisartan but not by empagliflozin.
Representative photographs of PAS stained sections for A) ctrl, B) ctrl + empa, C) dm, D) dm + empa and E) dm + tel groups and quantification of glomerulosclerosis by glomerulosclerotic index (F). Representative photographs of immunohistochemistry for glomerular fibronectin in G) ctrl, H) ctrl + empa, I) dm, J) dm + empa and K) dm + tel groups and quantification of glomerular fibronectin by Image J (L) (Magnification = original X400). Data are expressed as mean ± SEM with ** = P<0.001 vs ctrl, # = P<0.05 vs dm and ## = P<0.001 vs dm.