Inhibition of Kidney Proximal Tubular Glucose Reabsorption Does Not Prevent against Diabetic Nephropathy in Type 1 Diabetic eNOS Knockout Mice
Figure 1
Blood glucose levels among diabetic mice were matched throughout the study and showed similar glucose levels among the diabetic mice at 1, 2, 3, 4 and 5 months post diabetes induction and were significantly higher than control mice (A).
Empagliflozin reduced insulin requirement in diabetic mice (B). The comparison was made between average insulin requirement per dose administered thrice weekly, before and after initiation of empagliflozin. Data are expressed as mean ± SEM with * = P<0.05 and ** = P<0.001 vs ctrl.