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Interactive Local Super-Resolution Reconstruction of Whole-Body MRI Mouse Data: A Pilot Study with Applications to Bone and Kidney Metastases

Figure 5

Right humerus.

From left to right: a CT scan, a single low-resolution image (1 LR), and SRR reconstructions, each based on a different number of low-resolution images. Two orthogonal slices of the same VOI are shown to illustrate the effect of the SRR in a 3D volume. The orange dashed line approximately indicates where the yz-slice (3rd row) intersects the xy-slice (2nd row). The red arrows point to the tumor. The green arrows point to some of the locations where recovery of the fine details is the most noticeable. The CT and all the MR images are shown in the coordinate system associated with the principal axes of the bone, and the low-resolution volume is resampled to isotropic resolution beforehand. Image contrast on the MRI images was increased for visualization purposes. For all MR images the corresponding frequency spectra up to the Nyquist frequency of the reconstruction volume are shown, above and beneath the xy-slices and the yz-slices, respectively, demonstrating enhanced high-frequency content.

Figure 5

doi: https://doi.org/10.1371/journal.pone.0108730.g005