Runx2-I Isoform Contributes to Fetal Bone Formation Even in the Absence of Specific N-Terminal Amino Acids
Figure 9
Runx2-Ineo/neo mice showed decreased bone density.
(A) Mineralization of E18.5 fetuses of wild-type (+/+), Runx2-Ineo/+ (neo/+) and Runx2-Ineo/neo (neo/neo) mice was assessed by microcomputed tomography of the whole body (upper panels) and the skull (lower panels). Scale bars: 5 mm. (B) Quantitative bone mineral parameters were calculated from femur measurements. All the parameters of Runx2-Ineo/neo mice showed significantly severe deficiency of bone formation. Interestingly, Runx2-Ineo/+ mice did not exhibit any abnormalities compared with wild-type littermates. Data are means ± SEM (n = 4–9/group); *p<0.05, **p<0.01.