Efficient Drug Delivery of Paclitaxel Glycoside: A Novel Solubility Gradient Encapsulation into Liposomes Coupled with Immunoliposomes Preparation
Figure 7
Anticancer efficacy of different gPTX formulations with single administration in HT-29 cells tumor-bearing mice.
When the tumor volume reached 50–200 mm3, gPTX-IL at the dose of 150 (open circle with solid line), 100 (open circle with broken line), 50 (brown circle with solid line), or 10 mg/kg (brown circle with broken line), gPTX-L at the dose of 150 mg/kg (open triangle), gPTX-L at the dose of 150 mg/kg with 150 mg/kg trastuzumab (gPTX-L + Tras, open square), naked gPTX at the dose of 100 mg/kg (open diamond), trastuzumab (Tras, closed square), CEP-IL (closed circle), or PBS (cross) was intravenously injected. A, Tumor weights at day 30. B, Changes in body weight. Data are presented as the mean ± S.D. *, P<0.05 compared with PBS.