Efficient Drug Delivery of Paclitaxel Glycoside: A Novel Solubility Gradient Encapsulation into Liposomes Coupled with Immunoliposomes Preparation
Figure 4
Comparison of the encapsulation efficiency (EE), loading efficiency (LE), and particle size.
A, EE. B, LE. C, particle size. #Control indicated that gPTX-L was prepared with liposomes encapsulating 40% EG in 1 mg/mL gPTX. Comparison of stability at 4°C in PBS with PTX-L and gPTX-L prepared by the solubility gradient method. D, The retention rates of PTX-L (open circle) and gPTX-L (open triangle) were evaluated by HPLC. E, TEM images of PTX-L and gPTX-L. Each formulation was observed after 4 days of incubation. Each data point is presented as the mean ± S.D. (n = 3). *, P<0.05.