Relationships between Signaling Pathway Usage and Sensitivity to a Pathway Inhibitor: Examination of Trametinib Responses in Cultured Breast Cancer Lines
Figure 8
Relationship between drug sensitivity and pathway utilization in MCF-7 parental and sub-lines.
IC50 values for trametinib are represented on the y-axis and individual cell lines on the x-axis. Relative level of phosphorylation of p70S6K, AKT and ERK of breast cancer cell lines are shown as bar graphs. Bands are normalized to tubulin or actin control and bars represent changes in fold compared with MCF-7 and expressed as the mean from two experiments. Cell lines are colored orange for estrogen receptor positive (ER), and triple-negative (TN) in their respective rows.