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Relationships between Signaling Pathway Usage and Sensitivity to a Pathway Inhibitor: Examination of Trametinib Responses in Cultured Breast Cancer Lines

Figure 1

Schematic representation of a network of PI3K, mTOR and MEK complex signaling.

Blue arrows and black lines represent activating and inhibitory connections, respectively.

doi: https://doi.org/10.1371/journal.pone.0105792.g001