Effects of GWAS-Associated Genetic Variants on lncRNAs within IBD and T1D Candidate Loci
Figure 1
Schematic outline of the analysis pipeline.
The summary of the steps involved in this study. All human lncRNAs (sense exonic, sense non-exonic, antisense and intergenic) located within and in close proximity (5 kb up/downstream) of the IBD and T1D candidate genes were identified. Based on the above described workflow, we predicted potential lncRNA secondary structure-disruptive GWAS SNPs within the IBD and T1D loci-associated lncRNAs. cis-eQTL signals were identified for these lncRNAs and linkage disequilibrium analysis was also explored for selected SNPs. We exploited HapMap data to identify candidate lncRNAs under recent positive selection.