The Jak2 Small Molecule Inhibitor, G6, Reduces the Tumorigenic Potential of T98G Glioblastoma Cells In Vitro and In Vivo
Figure 7
Reduced Tumor Volumes Correlate with Decreased Levels of phospho-Jak2 and phospho-STAT3.
Shown are representative tumor sections, from the same nine mice described in Figure 6, after they were fixed, sectioned, and stained. For the H&E stained sections, mitotic cells are indicated by the green arrowheads. For pJak2, pSTAT3, Ki-67, and trichrome, the relative intensity of staining was quantified via relative pixel counting. Average pixel counts were then plotted as a function treatment group. The objective lens magnifications were either 50X (H&E) or 40X (pJak2, pSTAT3, Ki-67, and Trichrome). Scale bar = 50 µm. *, p<0.05, **, p<0.01.