The Jak2 Small Molecule Inhibitor, G6, Reduces the Tumorigenic Potential of T98G Glioblastoma Cells In Vitro and In Vivo
Figure 6
G6 reduces tumor volume in T98G xenografts and this is coincident with increased expression of BIM and BAX.
A) After establishment of the tumors, mice began receiving daily injections of either DMSO (n = 4) or 10 mg/kg G6 (n = 5) at Day 0. Tumor volumes are plotted as a function of both treatment condition and time. B) Average mRNA levels of various apoptotic markers taken from the tumors. *, p<0.05, **, p<0.01.