Establishment of a Rat Model of Portal Vein Ligation Combined with In Situ Splitting
Figure 5
Biochemical indications after different surgical interventions at all time points.
Serum levels of ALT (A), AST (B), ALB (C) and TBIL (D). Values are means±SD. There was a significant difference in ALT and AST release between PVL and PVL+ISS at 24 h (*p<0.05) after surgery and between PVL or PVL+ISS and SHAM at 24 and 48 h (#p<0.01). Then, they returned to baseline values at 72 h. No significant difference was observed at 72 h and 7 days in all groups. Hepatocellular synthetic function evaluated by serum albumin level showed a prolonged dysfunction in both PVL and PVL+ISS groups (#P<0.05 compared with the sham group at all time points). The serum albumin level of PVL+ISS was significantly different at 24, 48 and 72 h compared with the PVL group (*p<0.05). The serum levels of TBIL in all groups were not significantly different at any time point.