PDGF-BB Does Not Accelerate Healing in Diabetic Mice with Splinted Skin Wounds
Figure 3
Soluble PDGF-BB promotes proliferation of primary foreskin fibroblasts over 5 days, and can be attenuated by blocking PDGF beta receptors.
(A) A trimodal dose dependent response was observed with peak proliferation at 7.5 ng/ml, 7.5 and 50 µg/ml. Results are Mean ± StDev, n = 6. (B) Cell proliferation over 5 days was inhibited for all concentrations of PDGF-BB when PDGF-B receptor in cells were blocked with 10 µg/ml of PDGF beta receptor antibody for 30 min at 37°C prior to cell seeding. Results are Mean ± StDev, n = 6. * P<0.05, *** P<0.001.