Cucurbitacin E Induces Cell Cycle G2/M Phase Arrest and Apoptosis in Triple Negative Breast Cancer
Figure 1
Identification of CuE as a potent anti-cancer compound in different cancer cell lines, including TNBC cell lines.
A. Four different cancer cell lines were treated with 12 different cucurbitacins (10 µM) for 48 h. Cell viability was measured with the SRB assay. DMSO was used as the negative control. 1. Jinfushanencin B; 2. Cucurbitacin B; 3. 23, 24-dihydrocucurbitacin B; 4. 23,24-dihydrocucurbitacin D; 5. Cucurbitacin E; 6.22, 23-Dihydrocucurbitacin E; 7. 25-acetoxy-23,24-dihydrocucurbitacin F; 8. 23,24-dihydrocucurbitacin F; 9. Cucurbitacin L; 10. Kinoin B; 11. Endecaphyllacin A; 12. Elaeocarpucin C. Five potent anti-cancer compounds were labeled with underline. B. Chemical structure of CuE. C. Five different TNBC breast cancer cell lines treated with different concentrations (0–100 nM)) of CuE. Cell viability was measured with the SRB assay.