Arsenic Trioxide Reactivates Proteasome-Dependent Degradation of Mutant p53 Protein in Cancer Cells in Part via Enhanced Expression of Pirh2 E3 Ligase
Figure 1
Arsenic-induced degradation of mutant p53 protein is inhibited by MG132, an inhibitor of 26S proteasome.
Western blots were prepared with extracts from HaCaT (A) and MIA PaCa-2 (B) cells, which were untreated or pretreated with 4 µM MG132 for 2 h, and then untreated or treated with ATO for 6 h.