Interferon Regulatory Factor-5 Deficiency Ameliorates Disease Severity in the MRL/lpr Mouse Model of Lupus in the Absence of a Mutation in DOCK2
Figure 7
Serum BLyS levels are elevated in MRL/lpr mice but are not affected by IRF5 deficiency.
A and B. BLyS levels in the sera of IRF5+/+ MRL/lpr mice and IRF5−/− MRL/lpr mice (A), and C57BL/6 mice (B) at several ages were measured by ELISA. C. BLyS levels in the sera of sixteen week old IRF5+/+ (n = 11), IRF5+/− (n = 6) and IRF5−/− (n = 11) female MRL/lpr mice were measured by ELISA. The BLyS serum levels of the C57BL/6 mice (n = 10) shown in figure 7B (age range 13–32 weeks) are included for data comparison. Bars represent mean ± SEM. No significant differences were found between any of the MRL/lpr experimental groups.