Interferon Regulatory Factor-5 Deficiency Ameliorates Disease Severity in the MRL/lpr Mouse Model of Lupus in the Absence of a Mutation in DOCK2
Figure 6
Increased survival in IRF5-deficient MRL/lpr mice.
IRF5+/+ (n = 12), IRF5+/− (n = 14) and IRF5−/− (n = 14) female MRL/lpr littermates were observed until they met the criteria for euthanasia based on predetermined humane endpoints. ** p<0.01.