Interferon Regulatory Factor-5 Deficiency Ameliorates Disease Severity in the MRL/lpr Mouse Model of Lupus in the Absence of a Mutation in DOCK2
Figure 5
Less severe renal disease in IRF5-deficient MRL/lpr mice.
A and B, Kidneys from IRF5+/+ (n = 13), IRF5+/− (n = 10) and IRF5−/− (n = 10) female MRL/lpr littermates were analyzed at 16 weeks of age. Renal disease was quantified by measuring the percentage of glomeruli in each mouse showing evidence of mesangial expansion (A), and the percentage of glomeruli in each mouse with crescents or necrosis (B). C, Serum BUN levels in IRF5+/+ (n = 12), IRF5+/− (n = 12) and IRF5−/− (n = 12) female MRL/lpr littermates at 16 weeks of age. Bars represent mean ± SEM. *p<0.05; **p<0.01.