Interferon Regulatory Factor-5 Deficiency Ameliorates Disease Severity in the MRL/lpr Mouse Model of Lupus in the Absence of a Mutation in DOCK2
Figure 4
Decreased serum IgG2a, IgG2b and IgG3 levels in IRF5-deficient MRL/lpr mice.
Sera from IRF5+/+ (n = 12), IRF5+/− (n = 11) and IRF5−/− (n = 8) female MRL/lpr littermates were analyzed at 16 weeks of age. IgG and IgM levels were measured by ELISA. Bars represent mean ± SEM. **p<0.01.