Interferon Regulatory Factor-5 Deficiency Ameliorates Disease Severity in the MRL/lpr Mouse Model of Lupus in the Absence of a Mutation in DOCK2
Figure 3
Decreased autoantibody production in IRF5-deficient MRL/lpr mice.
Sera from IRF5+/+, IRF5+/− and IRF5−/− female MRL/lpr littermates were analyzed at 16 weeks of age. Anti-nuclear antibody (ANA) titers were measured by HEp2 cell immunofluorescence (left-hand panel) and anti-double stranded DNA (dsDNA) antibodies were measured by Crithidia lucillae luminescence (right-hand panel). Bars represent mean ± SEM. *p<0.05; **p<0.01.