Macrophage-Activating Lipopeptide-2 Requires Mal and PI3K for Efficient Induction of Heme Oxygenase-1
Figure 9
Schematic model depicting the potential signaling pathway involved in MALP-2-induced HO-1 expression in THP-1 cells.
The cytoplasmic adaptor Mal recruits the TLR2/6 heterodimer in response to MALP-2 stimulation. Mal binds to p85α, the regulatory subunit of PI3K, in the presence of Btk and c-Src. PI3K activates downstream events like Akt phosphorylation and Nrf2 nuclear translocation, which in turn initiates HO-1 expression.