Novel Compound Heterozygous Mutations in MYO7A Associated with Usher Syndrome 1 in a Chinese Family
Figure 5
Structure of wild-type and mutant myosin VIIa.
A: G25 in the wild-type protein has no side chain to interact with the His9 and Met59. B: The distance (dotted lines) between the long side chain of R25 and the residues H9 and M59 in the mutant protein were less than 3.5Å, which is shorter enough to form new hydrogen bonds (Created by SWISS-MODEL and shown with PY-MOL).