PARP-Inhibitor Treatment Prevents Hypertension Induced Cardiac Remodeling by Favorable Modulation of Heat Shock Proteins, Akt-1/GSK-3β and Several PKC Isoforms
Figure 7
Effect of L-2286 administration of PKC isoenzymes.
Representative Western blot analysis of PKC δThr505, εSer729 and ζ/λThr410/403 phosphorylation and densitometric evaluation is shown (n = 4). Actin was used as loading control. Values are means±S.E.M. WKY: normotensive age-matched control rats. SHR-C: 30 week-old spontaneously hypertensive rats, SHR-L: 30 week-old spontaneously hypertensive rats treated with L-2286 for 24 weeks. *p<0.01 vs. WKY, †p<0.01 vs. SHR-C.