PARP-Inhibitor Treatment Prevents Hypertension Induced Cardiac Remodeling by Favorable Modulation of Heat Shock Proteins, Akt-1/GSK-3β and Several PKC Isoforms
Figure 5
Effect of L-2286 on the phosphorylation state of MAPK pathway.
Representative Western blot analysis of ERK 1/2Thr183-Tyr185, and p38-MAPKThr180-Gly-Tyr182 phosphorylation and densitometric evaluation is shown (n = 4). Actin was used as loading control. Values are means±S.E.M. WKY: normotensive age-matched control rats. SHR-C: 30 week-old spontaneously hypertensive rats, SHR-L: 30 week-old spontaneously hypertensive rats treated with L-2286 for 24 weeks. §p<0.05 vs. WKY *p<0.01 vs. WKY.