PARP-Inhibitor Treatment Prevents Hypertension Induced Cardiac Remodeling by Favorable Modulation of Heat Shock Proteins, Akt-1/GSK-3β and Several PKC Isoforms
Figure 2
L-2286 treatment decreased the deposition of interstitial collagen.
Sections stained with Masson's trichrome (n = 5). Scale bars mean 200 µm. Magnifications 10-fold. WKY (A): normotensive age-matched control rats. SHR-C (B): 30 week-old spontaneously hypertensive rats, SHR-L (C): 30 week-old spontaneously hypertensive rats treated with L-2286 for 24 week. D: Denzitometric evaluation of the sections is shown. *p<0.01 vs. WKY, §p<0.05 vs. WKY, $p<0.05 vs. SHR-C.