A Small Molecule p75NTR Ligand, LM11A-31, Reverses Cholinergic Neurite Dystrophy in Alzheimer's Disease Mouse Models with Mid- to Late-Stage Disease Progression
Figure 10
LM11A-31 prevents dystrophy of cholinergic neurites in mid- to late-stage female Tg2576 mice.
Quantitative analysis showed that treating female Tg2576 mice starting at 14 months of age with LM11A-31 for 3 months prevented and/or reversed the decreases in (A) length, (B) surface area, and (C) branching of BFCN neurites. This treatment also decreased the total area (D) occupied by the clusters of cholinergic dystrophic neurites in the cortex and the mean area per cluster (F) but did not affect the number (E). Statistical significance was determined using an ANOVA with Dunnett's post-hoc test for BFCN neurite degeneration, a 2×2 contingency table with a Fisher's exact test for branching, and a two-tailed Student's t-test for clusters (nTg-Veh, n = 7 mice; Tg2576-Veh, n = 6; Tg2576-31, n = 5; nTg–LM11A-31, n = 4). *p≤0.05 vs. nTg veh; +p≤0.05 vs. Tg2576-Veh.