A Small Molecule p75NTR Ligand, LM11A-31, Reverses Cholinergic Neurite Dystrophy in Alzheimer's Disease Mouse Models with Mid- to Late-Stage Disease Progression
Figure 8
LM11A-31 prevents cholinergic dystrophic neurites in cortex of late-stage APPL/S mice.
Representative photomicrographs show clusters of cholinergic dystrophic neurites in the cortex of APPL/S (APP) Veh (A) and APP-31 (B) mice. Scale bar in B = 50 µm. Quantitative analysis showed that LM11A-31 did not significantly affect the total area (C) or number (D) of clusters but did decrease the size or mean area per cluster (E). Statistical significance was determined using a two-tailed Student's t-test. ++p≤0.01 vs. APP Veh.