A Small Molecule p75NTR Ligand, LM11A-31, Reverses Cholinergic Neurite Dystrophy in Alzheimer's Disease Mouse Models with Mid- to Late-Stage Disease Progression
Figure 2
Brain concentrations of LM11A-31 delivered ad libitum in drinking water of C57BL/6 mice.
LM11A-31 was given to C57BL/6 mice ad libitum in drinking water for 3 weeks at targeted doses of 10, 50, 75 and 100 mg/kg/day (n = 3–4 mice/dose). Brain concentrations were determined by LC-MS/MS by Absorption Systems (Exton, PA).