Pesticide Methoxychlor Promotes the Epigenetic Transgenerational Inheritance of Adult-Onset Disease through the Female Germline
Figure 2
Ancestral exposure to methoxychlor and transgenerational pubertal abnormalities, and ovarian and uterine diseases.
Percentages of females F1 and F3 generation (panel A) and males (panel B) with pubertal abnormality or females with ovarian disease (panel C) or uterine infection (panel D). Percentages of the F1 and F3 generation females with primordial follicle loss (panel E) and polycystic ovary disease (panel F) in control and methoxychlor lineages. The number of diseased rats / total number of rats in each lineage are also shown. (** P<0.01; *** P<0.001).