Chronopharmacodynamics and Chronopharmacokinetics of Pethidine in Mice
Figure 4
Influence of dosing time on recovery from tolerance after 2-day washout period.
Full legend: Influence of dosing time on recovery from tolerance after a single meperidine (20 mg/kg i.p.) or saline injection at 3:00 pm, followed by a 2-day washout period after 5-day meperidine or saline injection at 9:00 am or 9:00 pm (□, 9:00 am; ▪, 9:00 pm). Each value represents the mean with SD. *P<0.05, **P<0.01 comparison between groups using Scheffe's test. A, a single saline injection after 5-day saline injection at 9:00 am. B, a single saline injection after 5-day saline injection at 9:00 pm. C, a single meperidine injection after 5-day saline injection at 9:00 am. D, a single meperidine injection after 5-day saline injection at 9:00 pm. E, a single meperidine injection after 5-day meperidine injection at 9:00 am. F, a single meperidine injection after 5-day meperidine injection at 9:00 pm.