Chronopharmacodynamics and Chronopharmacokinetics of Pethidine in Mice
Figure 3
Influence of dosing time on tolerance after 5-day meperidine injection at day or night.
Full legend: Influence of dosing time on tolerance to analgesia at 30 min after 5-day meperidine or saline injection at 9:00 am or 9:00 pm. Each value represents the mean with SD. *P<0.05, **P<0.01 compared with the corresponding saline group, and #P<0.05, ##P<0.01 comparison between two dosing time using Scheffe's test.