A Small Molecule Inhibitor of Human RAD51 Potentiates Breast Cancer Cell Killing by Therapeutic Agents in Mouse Xenografts
Figure 5
The effect of cisplatin and B02 on the time course of tumor growth, A.
After 11 days of tumor inoculation, tumors were touchable. Then mice were randomly regrouped (n = 5) and treated on day 11, 13, 15, 17 with either B02 (50 mg/kg), cisplatin (4 mg/kg), or a combination of both. Mice untreated or treated with vehicle (20% DMSO, 20% cremophor, 60% NS) were shown as controls. The tumor volumes were monitored by caliper measurement in each group. The time course of tumor growth presented as a graph. Error bars represent SD. Direct measurement of the weight of tumors tissues dissected from the mice after indicated treatment, B. Mice were sacrificed 43 days after tumor inoculation and the tumors were dissected. The weight of tumors shown in panel B presented as a graph, C. Error bars represent SD.