Erucin, the Major Isothiocyanate in Arugula (Eruca sativa), Inhibits Proliferation of MCF7 Tumor Cells by Suppressing Microtubule Dynamics
Figure 5
Concentration-dependent suppression of dynamic instability at microtubule plus-ends in vitro by erucin.
Microtubule ends were tracked over time to produce life history plots of individual microtubules assembled in vitro from purified bovine brain tubulin. Life history plots are the length changes of individual microtubules in controls (A), and in the presence of 15 µM erucin (B). (C) Concentration-dependent suppression of microtubule dynamics parameters in vitro by erucin: the growth rate (♦), growth length (◊), shortening rate (▪), shortening length (□), and dynamicity (×). Data are from Table 2.