MutLα Heterodimers Modify the Molecular Phenotype of Friedreich Ataxia
Figure 5
Effect of the MutLα-complex on FXN transcription in vitro.
Relative RT-qPCR analyses of the mean FXN transcriptional level, isolated from MMR-proficient human cells, NCM-460, and MutLα heterodimer-deficient cells, HCT-116 (n = 3). Statistical analysis of the experiment was perform using the student's t test. Error bars = S.E.M, * = p<0.05, ** = p<0.01, *** = p<0.001.