Contribution of a Non-β-Cell Source to β-Cell Mass during Pregnancy
Figure 5
mRNA expression of upstream regulators and downstream targets of Ngn3.
mRNA expression of upstream regulators (Pdx-1, Sox9, and Hes-1,) and downstream targets (Tle3, NeuroD, Nkx2.2, IA1, and Rfx6,) of Ngn3. Islets were isolated from Ngn3+/+ mice at G0, G6, G9, and G15. Results represent the mean of 3 separate experiments, and expression levels were compared by one-way ANOVA. “*”: p<0.05 by Tukey’s multiple comparison test against G0. N = 6 separate mice at each gestational age.