Focused Ultrasound Simultaneous Irradiation/MRI Imaging, and Two-Stage General Kinetic Model
Figure 5
Estimation of the changes in Gd concentration using GKM or Two-stage GKM.
(A) estimation of the changes in Gd concentration at the right hemisphere of the rat's brain tissue for the single FUS irradiation experiment using GKM; (B) estimation of the changes in Gd concentration in the right hemisphere of the rat's brain tissue for the repeated FUS irradiation experiment using GKM; (C) based on the condition in (B), estimation of the changes in Gd concentration in the right hemisphere of the rat's brain tissue for the repeated FUS irradiation experiment using Two-stage GKM; (D) list of the permeability values Ktrans and Kep estimated from (B) and (C). The data points in the figure show the changes in Gd concentration with time in the right hemisphere of the rat's brain tissue due to FUS irradiation. The curve was estimated using GKM or Two-stage GKM.