Macrophage Inflammatory Protein-1α Shows Predictive Value as a Risk Marker for Subjects and Sites Vulnerable to Bone Loss in a Longitudinal Model of Aggressive Periodontitis
Figure 2
Salivary cytokines from healthy and bone loss subjects: Cytokines elevated prior to bone loss.
Saliva from healthy subjects was compared to subjects who developed bone loss. The cytokines that showed significant differences are illustrated 6 months prior to bone loss and compared to levels at the time bone loss was detected (labeled disease) and to salivary levels found in subjects who started healthy and remained healthy. Letters that are different (A vs B) are significantly different at the p<0.05 level. Cytokines MIP-1α, MIP-1β, IL-1β, and IL-8 are all significantly elevated 6-mo. before BL when compared to saliva from healthy subjects and to saliva at the time disease was detected. IL-1α is significantly elevated prior to BL as compared to saliva from healthy subjects but is not significantly different than that seen at the time of disease detection.