Decreased Basal Ganglia Activation in Subjects with Chronic Fatigue Syndrome: Association with Symptoms of Fatigue
Figure 3
Correlation between Fatigue and Globus Pallidus Activation in CFS and Controls.
Scores on the mental fatigue, general fatigue and reduced activity subscales of the Multidimensional Fatigue Inventory (MFI) are plotted against the percent BOLD signal change corresponding to the Win-Lose contrast averaged across all region of interest (ROI) voxels in the right globus pallidus: blue = nonfatigued (NF) controls, red = chronic fatigue syndrome (CFS) subjects. Relationships were assessed in each group separately using Bravais-Pearson correlations. Significant correlations were found between neural activity in the right globus pallidus and mental fatigue, general fatigue and reduced activity in CFS subjects (all p<0.05) but not in controls.