Decreased Basal Ganglia Activation in Subjects with Chronic Fatigue Syndrome: Association with Symptoms of Fatigue
Figure 2
Reduced Activation in Basal Ganglia Structures in CFS compared to Controls for the Win-Lose Contrast.
Box plot of activation [percent blood oxygen level-dependent (BOLD) signal change corresponding to the Win-Lose contrast averaged across all region of interest (ROI) voxels] in basal ganglia structures: blue = nonfatigued (NF) controls, red = chronic fatigue syndrome (CFS) subjects. Univariate analyses of group differences in specific ROIs revealed that CFS subjects exhibited significantly reduced neural activity compared to NF controls in the right caudate and right globus pallidus and each of these structures bilaterally (all p<0.05).