The Hepatoselective Glucokinase Activator PF-04991532 Ameliorates Hyperglycemia without Causing Hepatic Steatosis in Diabetic Rats
Figure 3
PF-04991532 effects on lipid metabolism and downstream hepatic metabolites.
Expression of key lipid, carbohydrate, and cholesterol metabolism genes in rats treated with an acute 100/kg dose of PF-04991532 relative to vehicle (A). The increase in expression of the lipogenic genes can be explained by the increased nuclear ChREBP (n = 3/4/group) (B). Lastly, a metabolic profile of key metabolites using 31P-NMR and 1H-NMR in rats treated with an acute dose of PF-04991532 (n = 5–6/group) (C). *P<0.05; #P<0.1 for Vehicle vs. 100 mg/kg PF-04991532. Student’s t-test was used.