Transient Receptor Potential Ankyrin 1 Receptor Activation In Vitro and In Vivo by Pro-tussive Agents: GRC 17536 as a Promising Anti-Tussive Therapeutic
Figure 2
Blockade of citric acid-induced Ca+2 influx by TRPA1 and TRPV1 antagonists.
(A–B) Inhibition of citric acid-induced Ca+2 influx by GRC 17536, compound 7 and GRC 6211 in CCD19-Lu (A) and A549 (B) cells. (C) Inhibition of citric -induced Ca+2 influx by GRC 17536, compound 7 and GRC 17770 in hTRPA1/CHO cells. Each point in the graph is an average ± SEM of at least two independent experiments.