Identification of Selective Small Molecule Inhibitors of the Nucleotide-Binding Oligomerization Domain 1 (NOD1) Signaling Pathway
Figure 2
Activity of three structurally distinct selective NOD1 pathway inhibitors.
(A) Chemical structure of the original hits in each series. (B–D) Concentration response curves for inhibition of IL-8 release by 293/hNOD1 and 293/hNOD2 stable cell lines stimulated with iE-DAP or MDP, respectively, and pre-incubated with the xanthine SB711 (B), quinazolininone GSK223 (C) or aminobenzothiazole GSK966 (D) over the concentration range 2.5 nM –50 µM. Data are the mean ± SD from at least 5 (293/hNOD1– iE-DAP) and from 2 (293/hNOD2– MDP) separate assays for each compound.