Sorafenib Metabolism Is Significantly Altered in the Liver Tumor Tissue of Hepatocellular Carcinoma Patient
Figure 4
Inter-individual variability of sorafenib metabolism by UGT1A9 with 18 human liver microsomes samples (THLMs and NHLMs).
Sorafenib (2.5 µM) was incubated with microsomes (0.133 mg/ml) obtained from different patients for 90 min at 37°C. The formation rate of M7 expressed as peak area ratio (mean ± SD). All the experiments were performed in triplicate. Student’s T-test analysis was used for data analysis. “*” denotes statistical significance (P<0.05).